S100a9 deficiency accelerates MDS-associated tumor escape via PD-1/PD-L1 overexpression

In recent studies, the tolerable safety profile and positive bone marrow (BM) response suggest a beneficial use of anti-PD-1 agents in the treatment of Myelodysplastic Syndromes (MDS), but the underlying mechanism is still unknown. MDS is mainly characterized by ineffective hematopoiesis, which may...

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Bibliographic Details
Main Authors: Wang Roujia, Zhao Youshan, Li Zijuan, Guo Juan, Zhao Sida, Song Luxi, Wu Dong, Wang Lan, Chang Chunkang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-02-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023015