Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction
Abstract Cardiopulmonary exercise testing (CPET) may potentially differentiate heart failure (HF) with preserved ejection fraction (HFpEF) from noncardiac causes of dyspnea (NCD). While contemporary guidelines for HF recommend using CPET for identifying causes of unexplained dyspnea, data supporting...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-31381-6 |
| _version_ | 1797864700731457536 |
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| author | Yuki Saito Masaru Obokata Tomonari Harada Kazuki Kagami Makoto Murata Hidemi Sorimachi Toshimitsu Kato Naoki Wada Yasuo Okumura Hideki Ishii |
| author_facet | Yuki Saito Masaru Obokata Tomonari Harada Kazuki Kagami Makoto Murata Hidemi Sorimachi Toshimitsu Kato Naoki Wada Yasuo Okumura Hideki Ishii |
| author_sort | Yuki Saito |
| collection | DOAJ |
| description | Abstract Cardiopulmonary exercise testing (CPET) may potentially differentiate heart failure (HF) with preserved ejection fraction (HFpEF) from noncardiac causes of dyspnea (NCD). While contemporary guidelines for HF recommend using CPET for identifying causes of unexplained dyspnea, data supporting this practice are limited. This study aimed to determine the diagnostic value of expired gas analysis to distinguish HFpEF from NCD. Exercise stress echocardiography with simultaneous expired gas analysis was performed in patients with HFpEF (n = 116) and those with NCD (n = 112). Participants without dyspnea symptoms were also enrolled as controls (n = 26). Exercise capacity was impaired in patients with HFpEF than in controls and those with NCD, evidenced by lower oxygen consumption (VO2), but there was a substantial overlap between HFpEF and NCD. Receiver operating characteristic curve analyses showed modest diagnostic abilities of expired gas analysis data in differentiating individuals with HFpEF from the controls; however, none of these variables clearly differentiated between HFpEF and NCD (all areas under the curve < 0.61). Expired gas analysis provided objective assessments of exercise capacity; however, its diagnostic value in identifying HFpEF among patients with symptoms of exertional dyspnea was modest. |
| first_indexed | 2024-04-09T22:57:24Z |
| format | Article |
| id | doaj.art-8425b5a01a1e40af8fb18c049fd9829d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:57:24Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8425b5a01a1e40af8fb18c049fd9829d2023-03-22T11:12:03ZengNature PortfolioScientific Reports2045-23222023-03-011311910.1038/s41598-023-31381-6Diagnostic value of expired gas analysis in heart failure with preserved ejection fractionYuki Saito0Masaru Obokata1Tomonari Harada2Kazuki Kagami3Makoto Murata4Hidemi Sorimachi5Toshimitsu Kato6Naoki Wada7Yasuo OkumuraHideki Ishii8Department of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Cardiology, Gunma Prefectural Cardiovascular CenterDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineDepartment of Rehabilitation Medicine, Gunma University Graduate School of MedicineDepartment of Cardiovascular Medicine, Gunma University Graduate School of MedicineAbstract Cardiopulmonary exercise testing (CPET) may potentially differentiate heart failure (HF) with preserved ejection fraction (HFpEF) from noncardiac causes of dyspnea (NCD). While contemporary guidelines for HF recommend using CPET for identifying causes of unexplained dyspnea, data supporting this practice are limited. This study aimed to determine the diagnostic value of expired gas analysis to distinguish HFpEF from NCD. Exercise stress echocardiography with simultaneous expired gas analysis was performed in patients with HFpEF (n = 116) and those with NCD (n = 112). Participants without dyspnea symptoms were also enrolled as controls (n = 26). Exercise capacity was impaired in patients with HFpEF than in controls and those with NCD, evidenced by lower oxygen consumption (VO2), but there was a substantial overlap between HFpEF and NCD. Receiver operating characteristic curve analyses showed modest diagnostic abilities of expired gas analysis data in differentiating individuals with HFpEF from the controls; however, none of these variables clearly differentiated between HFpEF and NCD (all areas under the curve < 0.61). Expired gas analysis provided objective assessments of exercise capacity; however, its diagnostic value in identifying HFpEF among patients with symptoms of exertional dyspnea was modest.https://doi.org/10.1038/s41598-023-31381-6 |
| spellingShingle | Yuki Saito Masaru Obokata Tomonari Harada Kazuki Kagami Makoto Murata Hidemi Sorimachi Toshimitsu Kato Naoki Wada Yasuo Okumura Hideki Ishii Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction Scientific Reports |
| title | Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| title_full | Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| title_fullStr | Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| title_full_unstemmed | Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| title_short | Diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| title_sort | diagnostic value of expired gas analysis in heart failure with preserved ejection fraction |
| url | https://doi.org/10.1038/s41598-023-31381-6 |
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