Most non-canonical proteins uniquely populate the proteome or immunopeptidome

Most non-canonical proteins uniquely populate the proteome or immunopeptidome

Summary: Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the contribution of non-canonical translation to the proteome and major histocompatibility complex (MHC) class I immunopeptidome. Remarkably, of 14,498 proteins identified in three human B cell lymphomas, 2,50...

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Bibliographic Details
Main Authors: Maria Virginia Ruiz Cuevas, Marie-Pierre Hardy, Jaroslav Hollý, Éric Bonneil, Chantal Durette, Mathieu Courcelles, Joël Lanoix, Caroline Côté, Louis M. Staudt, Sébastien Lemieux, Pierre Thibault, Claude Perreault, Jonathan W. Yewdell
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
computational biology
defective ribosomal products
major histocompatibility complex
mass spectrometry
non-canonical translation
peptides
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721001297

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http://www.sciencedirect.com/science/article/pii/S2211124721001297

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