Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α

Objective: To clarify the potential therapeutic effects of thymoquinone (TQ) on pancreatic cancer and its gemcitabine (GEM) sensitivity.Methods: The expression levels of hypoxia inducible factor-1α (HIF-1α), collagens (COL1A1, COL3A1, and COL5A1), and transforming growth factor-β1 (TGFβ1) in pancrea...

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Bibliographic Details
Main Authors: Zhanxue Zhao, Linxun Liu, Hekai Chen, Shuai Li, Yan Guo, Xiaofan Hou, Jinyu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
thymoquinone
pancreatic cancer
HIF-1α
ECM production
gemcitabine
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1138265/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1138265/full

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