A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring

A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring

Background:. Connective tissue growth factor (CTGF) is a matricellular protein that plays a key role in wound healing and scar formation. Inhibition of CTGF by a specific antisense oligonucleotide significantly reduced scarring and fibrosis in animal models. This study examined whether an antisense...

Full description

Bibliographic Details
Main Authors: Jeremy D. Gale, PhD, Jeff Jensen, BS, Gabe Berman, BA, William Freimuth, MD, Gang Li, PhD, Andreas Pleil, PhD, Malik Kutty, MD, Andrew Rosenthal, MD, C.B. Boswell, MD, V., E. Magnus Noah, Dr. Med, Leroy Young, MD
Format: Article
Language:English
Published: Wolters Kluwer 2018-09-01
Series:Plastic and Reconstructive Surgery, Global Open
Online Access:http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000001861

Internet

http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000001861

Similar Items