IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes

IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes

Abstract Background Interleukin-27 (IL-27) can trigger both pro- and anti-inflammatory responses. This cytokine is elevated in the central nervous system (CNS) of multiple sclerosis (MS) patients, but how it influences neuroinflammatory processes remains unclear. As astrocytes express the receptor f...

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Bibliographic Details
Main Authors: Florent Lemaître, Negar Farzam-kia, Ana Carmena Moratalla, Yves Carpentier Solorio, Marie-Laure Clenet, Olivier Tastet, Aurélie Cleret-Buhot, Jean Victor Guimond, Elie Haddad, Pierre Duquette, J. Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Neuroinflammation
Subjects:
Cytokines
Glial cells
T lymphocytes
Transcription factors
T cell motility
Online Access:https://doi.org/10.1186/s12974-022-02572-1

Internet

https://doi.org/10.1186/s12974-022-02572-1

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