Bone marrow mesenchymal stem cell-derived endothelial cells increase capillary density and accelerate angiogenesis in mouse hindlimb ischemia model

Bone marrow mesenchymal stem cell-derived endothelial cells increase capillary density and accelerate angiogenesis in mouse hindlimb ischemia model

Abstract Background Mesenchymal stem cells (MSCs) can improve limb perfusion and increase vessel density in a murine model of hindlimb ischemia. But low engraftment rate of those cells limited their therapeutic effect. Endothelial cells (ECs) play an important role in neovascularization. And MSCs ca...

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Bibliographic Details
Main Authors: Ziping Yao, Huihui Liu, Min Yang, Yun Bai, Bihui Zhang, Chengen Wang, Ziguang Yan, Guochen Niu, Yinghua Zou, Yuan Li
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Endothelial cells
Hindlimb ischemia model
Angiogenesis
Engraftment
Online Access:http://link.springer.com/article/10.1186/s13287-020-01710-x

Internet

http://link.springer.com/article/10.1186/s13287-020-01710-x

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