Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study

Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [18F]FE-PE2I Positron Emission Tomography Analysis Study

Fas-associated factor 1 (FAF1), a Fas-binding protein, is implicated in neuronal cell death in Parkinson’s disease (PD). We examined the effects of a novel FAF1 inhibitor, KM-819, in dopaminergic neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model using [18F]FE-PE2I positron...

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Bibliographic Details
Main Authors: Hyun Soo Park, Yoo Sung Song, Byung Seok Moon, Sung-Eun Yoo, Jae Moon Lee, Yeon-Tae Chung, Eunhee Kim, Byung Chul Lee, Sang Eun Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
Fas-associated factor 1 inhibitor
KM-819
Parkinson’s disease
non-displaceable binding potential
positron emission tomography
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00953/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00953/full

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