Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection

Mitochondrial disturbance related to increased caspase-1 of CD4+T cells in HIV-1 infection

Abstract Background In HIV-1 infection, more than 95% of CD4+T cells die of caspase-1 mediated pyroptosis. What governs the increased susceptibility of CD4+T cells to pyroptosis is poorly understood. Methods Blood samples were obtained from 31 untreated HIV-infected patients (UNT), 29 antiretroviral...

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Bibliographic Details
Main Authors: Fengting Yu, Chengjie Ma, Xia Jin, Hongxin Zhao, Jiang Xiao, Li Li, Shujing Song, Xiaohui Xie, Siyuan Yang, Yunxia Tang, Linghang Wang, Fujie Zhang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Infectious Diseases
Subjects:
HIV/AIDS
CD4+T pyroptosis
Mitochondrial mass
MFN1
Online Access:https://doi.org/10.1186/s12879-023-08485-5

Internet

https://doi.org/10.1186/s12879-023-08485-5

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