Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat diet (HFD) and suggests additional control poin...

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Bibliographic Details
Main Authors: Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314809

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http://www.sciencedirect.com/science/article/pii/S2211124719314809

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