Synthesis, Physicochemical, Labeling and In Vivo Characterization of <sup>44</sup>Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe

Synthesis, Physicochemical, Labeling and In Vivo Characterization of <sup>44</sup>Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe

Hypoxia promotes angiogenesis, which is crucial for tumor growth, and induces malignant progression and increases the therapeutic resistance. Positron emission tomography (PET) enables the detection of the hypoxic regions in tumors using 2-nitroimidazole-based radiopharmaceuticals. We describe here...

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Bibliographic Details
Main Authors: Dániel Szücs, Tibor Csupász, Judit P. Szabó, Adrienn Kis, Barbara Gyuricza, Viktória Arató, Viktória Forgács, Adrienn Vágner, Gábor Nagy, Ildikó Garai, Dezső Szikra, Imre Tóth, György Trencsényi, Gyula Tircsó, Anikó Fekete
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
radiopharmaceutical
physicochemical study
scandium-44
radiochemistry
positron emission tomography
tumor hypoxia
Online Access:https://www.mdpi.com/1424-8247/15/6/666

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https://www.mdpi.com/1424-8247/15/6/666

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