Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma

Novel Thiol Containing Hybrid Antioxidant-Nitric Oxide Donor Small Molecules for Treatment of Glaucoma

Oxidative stress induced death and dysregulation of trabecular meshwork (TM) cells contribute to the increased intraocular pressure (IOP) in primary open angle (POAG) glaucoma patients. POAG is one of the major causes of irreversible vision loss worldwide. Nitric oxide (NO), a small gas molecule, ha...

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Bibliographic Details
Main Authors: Charles E. Amankwa, Sudershan R. Gondi, Adnan Dibas, Courtney Weston, Arlene Funk, Tam Nguyen, Kytai T. Nguyen, Dorette Z. Ellis, Suchismita Acharya
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
nitric oxide
superoxide radical
hybrid small molecule
glaucoma
intra-ocular pressure
nanosuspension
Online Access:https://www.mdpi.com/2076-3921/10/4/575

Internet

https://www.mdpi.com/2076-3921/10/4/575

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