Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

DJ-1 is a redox-sensitive protein with several putative functions important in mitochondrial physiology, protein transcription, proteasome regulation, and chaperone activity. High levels of DJ-1 immunoreactivity are reported in astrocytes surrounding pathology associated with idiopathic Parkinson�...

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Bibliographic Details
Main Authors: Briana R. De Miranda, Emily M. Rocha, Qing Bai, Amina El Ayadi, David Hinkle, Edward A. Burton, J. Timothy Greenamyre
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Astrocyte
Rotenone
Parkinson's disease
Chaperone-mediated autophagy
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301165

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http://www.sciencedirect.com/science/article/pii/S0969996118301165

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