Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168

Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168

E3 ubiquitin ligase RNF168 is important for the repair of DNA double-strand breaks and recognizes ubiquitylated targets through two Ub-dependent DSB recruitment modules UDM1 and UDM2. Here the authors combine crystallography, cell biology and biochemical experiments to reveal how UDM1 and UDM2 inter...

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Bibliographic Details
Main Authors: Tomio S. Takahashi, Yoshihiro Hirade, Aya Toma, Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Akiko Tomita, Shinichiro Nakada, Shuya Fukai
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02345-y

Internet

https://doi.org/10.1038/s41467-017-02345-y

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