Yeast surface display of leech hyaluronidase for the industrial production of hyaluronic acid oligosaccharides

Leech hyaluronidase (LHyal) is a hyperactive hyaluronic acid (HA) hydrolase that belongs to the hyaluronoglucuronidase family. Traditionally, LHyal is extracted from the heads of leeches, but the recent development of the Pichia pastoris recombinant LHyal expression method permitted the industrial p...

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Bibliographic Details
Main Authors: Lizhi Liao, Hao Huang, Yang Wang, Guocheng Du, Zhen Kang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Engineering Microbiology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667370323000188