Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Summary: “Shock and kill” strategies focus on purging the latent HIV-1 reservoir by treating infected individuals with therapeutics that activate the latent virus and subsequently eliminating infected cells. We have previously reported that induction of non-canonical nuclear factor κB (NF-κB) signal...

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Bibliographic Details
Main Authors: Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports Medicine
Subjects:
HIV
latency
Smac mimetics
latency reversal agents
LRA
non-canonical NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300495

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http://www.sciencedirect.com/science/article/pii/S2666379120300495

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