RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy

RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy

Acute myeloid leukemia (AML) is a rapidly progressing heterogeneous disease with a high mortality rate, which is characterized by hyperproliferation of atypical immature myeloid cells. The number of AML patients is expected to increase in the near future, due to the old-age-associated nature of AML...

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Bibliographic Details
Main Authors: Ekaterina I. Romanova, Anatoliy V. Zubritskiy, Anna V. Lioznova, Adewale J. Ogunleye, Vasily A. Golotin, Anna A. Guts, Andreas Lennartsson, Oleg N. Demidov, Yulia A. Medvedeva
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
AML
DNA methylation
RUNX1
CEBPA
TET2
epigenetics
Online Access:https://www.mdpi.com/1422-0067/23/19/11413

Internet

https://www.mdpi.com/1422-0067/23/19/11413

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