Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration

Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration

Abstract Background Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injury, verify the impacts of HCT on liver repair, and avoid harmful regener...

Full description

Bibliographic Details
Main Authors: Tian Lan, Yang Tai, Chong Zhao, Yang Xiao, Zhu Yang, Linhao Zhang, Can Gan, Wenting Dai, Huan Tong, Chengwei Tang, Zhiyin Huang, Jinhang Gao
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Inflammation and Regeneration
Subjects:
Hepatocyte-cholangiocyte transdifferentiation
Cyclooxygenase-2
β-catenin
TGF-β
Chronic liver injury
Liver regeneration
Online Access:https://doi.org/10.1186/s41232-023-00284-4

Internet

https://doi.org/10.1186/s41232-023-00284-4

Similar Items