TMED3 Complex Mediates ER Stress‐Associated Secretion of CFTR, Pendrin, and SARS‐CoV‐2 Spike

TMED3 Complex Mediates ER Stress‐Associated Secretion of CFTR, Pendrin, and SARS‐CoV‐2 Spike

Abstract Under ER stress conditions, the ER form of transmembrane proteins can reach the plasma membrane via a Golgi‐independent unconventional protein secretion (UPS) pathway. However, the targeting mechanisms of membrane proteins for UPS are unknown. Here, this study reports that TMED proteins pla...

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Bibliographic Details
Main Authors: Hak Park, Soo Kyung Seo, Ju‐Ri Sim, Su Jin Hwang, Ye Jin Kim, Dong Hoon Shin, Dong Geon Jang, Shin Hye Noh, Pil‐Gu Park, Si Hwan Ko, Mi Hwa Shin, Jae Young Choi, Yukishige Ito, Chung‐Min Kang, Jae Myun Lee, Min Goo Lee
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Advanced Science
Subjects:
CFTR
pendrin
SARS‐CoV‐2 spike
TMED
UPS
Online Access:https://doi.org/10.1002/advs.202105320

Internet

https://doi.org/10.1002/advs.202105320

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