Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function

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Dysregulation of dopaminergic transmission induced by the HIV-1 transactivator of transcription (Tat) has been implicated as a central factor in the development of HIV-1 associated neurocognitive disorders (HAND). We have demonstrated that the tyrosine470 residue of the human dopamine transporter (h...

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Bibliographic Details
Main Authors: Matthew J. Strauss, Katherine D. Porter, Pamela M. Quizon, Sarah E. Davis, Steven Lin, Yaxia Yuan, Gustavo A. Martinez-Muniz, Wei-Lun Sun, Chang-Guo Zhan, Jun Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518868/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518868/?tool=EBI

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