Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.

Bibliographic Details
Main Authors: Alexei Brooun, Ketan S. Gajiwala, Ya-Li Deng, Wei Liu, Ben Bolaños, Patrick Bingham, You-Ai He, Wade Diehl, Nicole Grable, Pei-Pei Kung, Scott Sutton, Karen A. Maegley, Xiu Yu, Al E. Stewart
Format: Article
Language:English
Published: Nature Portfolio 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11384

Internet

https://doi.org/10.1038/ncomms11384

Similar Items