Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
Bibliographic Details
| Main Authors: |
Alexei Brooun,
Ketan S. Gajiwala,
Ya-Li Deng,
Wei Liu,
Ben Bolaños,
Patrick Bingham,
You-Ai He,
Wade Diehl,
Nicole Grable,
Pei-Pei Kung,
Scott Sutton,
Karen A. Maegley,
Xiu Yu,
Al E. Stewart |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms11384
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