Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance
Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11384 |
| _version_ | 1818995078113263616 |
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| author | Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart |
| author_facet | Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart |
| author_sort | Alexei Brooun |
| collection | DOAJ |
| description | Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2. |
| first_indexed | 2024-12-20T21:08:07Z |
| format | Article |
| id | doaj.art-845df6d19e6c440e8657bbebe46e34a8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:08:07Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-845df6d19e6c440e8657bbebe46e34a82022-12-21T19:26:35ZengNature PortfolioNature Communications2041-17232016-04-017111210.1038/ncomms11384Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistanceAlexei Brooun0Ketan S. Gajiwala1Ya-Li Deng2Wei Liu3Ben Bolaños4Patrick Bingham5You-Ai He6Wade Diehl7Nicole Grable8Pei-Pei Kung9Scott Sutton10Karen A. Maegley11Xiu Yu12Al E. Stewart13Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Oncology Research Unit, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Oncology Research Unit, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Worldwide Medicinal Chemistry, Worldwide Research and Development, Pfizer Inc.Polycomb repressive complex 2 (PRC2) mediates gene silencing through chromatin reorganization by methylation of histone H3 lysine 27 (H3K27). Here, the authors present crystal structures of the inhibitor-bound wild-type and a mutant form of PRC2.https://doi.org/10.1038/ncomms11384 |
| spellingShingle | Alexei Brooun Ketan S. Gajiwala Ya-Li Deng Wei Liu Ben Bolaños Patrick Bingham You-Ai He Wade Diehl Nicole Grable Pei-Pei Kung Scott Sutton Karen A. Maegley Xiu Yu Al E. Stewart Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance Nature Communications |
| title | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| title_full | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| title_fullStr | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| title_full_unstemmed | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| title_short | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| title_sort | polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance |
| url | https://doi.org/10.1038/ncomms11384 |
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