Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1

Objective: Carfilzomib is a second-generation tetrapeptide epoxyketone proteasome inhibitor used in current clinical therapy of hematologic malignancies. The mechanism of proteasome inhibition in endometrial cancer is not very clear. Carfilzomib inhibition of type I endometrial carcinoma cell prolif...

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Bibliographic Details
Main Authors: Yuanyuan Zhou, Ke Wang, Shuai Zhen, Ruili Wang, Wenjuan Luo
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Subjects:
carfilzomib
cell cycle
endometrial carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455916302212

Internet

http://www.sciencedirect.com/science/article/pii/S1028455916302212

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