Functional screen of inflammatory bowel disease genes reveals key epithelial functions

Functional screen of inflammatory bowel disease genes reveals key epithelial functions

Abstract Background Genetic studies have been tremendously successful in identifying genomic regions associated with a wide variety of phenotypes, although the success of these studies in identifying causal genes, their variants, and their functional impacts has been more limited. Methods We identif...

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Main Authors: Jessy Carol Ntunzwenimana, Gabrielle Boucher, Jean Paquette, Hugues Gosselin, Azadeh Alikashani, Nicolas Morin, Claudine Beauchamp, Louise Thauvette, Marie-Ève Rivard, Frédérique Dupuis, Sonia Deschênes, Sylvain Foisy, Frédéric Latour, Geneviève Lavallée, Mark J. Daly, Ramnik J. Xavier, the iGenoMed Consortium, Guy Charron, Philippe Goyette, John D. Rioux
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Genome Medicine
Subjects:
Inflammatory bowel diseases
Type I interferon response
Mucosal immunity
Secretory immunoglobulins
Online Access:https://doi.org/10.1186/s13073-021-00996-7

Internet

https://doi.org/10.1186/s13073-021-00996-7

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