Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma

Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma

Abstract Background Extranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding of disease biology and key oncogenic process is necessary for the development of targeted therapy. Super-enhancers (SEs) have been shown to d...

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Bibliographic Details
Main Authors: Jianbiao Zhou, Sabrina Hui-Min Toh, Tze King Tan, Kalpnaa Balan, Jing Quan Lim, Tuan Zea Tan, Sinan Xiong, Yunlu Jia, Siok-Bian Ng, Yanfen Peng, Anand D. Jeyasekharan, Shuangyi Fan, Soon Thye Lim, Chin-Ann Johnny Ong, Choon Kiat Ong, Takaomi Sanda, Wee-Joo Chng
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Molecular Cancer
Subjects:
Super-enhancer
TOX2
Natural Killer/T Cell Lymphoma
RUNX3
PRL-3
Epigenetics
Online Access:https://doi.org/10.1186/s12943-023-01767-1

Internet

https://doi.org/10.1186/s12943-023-01767-1

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