A systematic evaluation of normalization methods and probe replicability using infinium EPIC methylation data

A systematic evaluation of normalization methods and probe replicability using infinium EPIC methylation data

Abstract Background The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes. These probe types exhibit different technical characteristics which may confound analyses. Numerous normalization and...

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Bibliographic Details
Main Authors: H. Welsh, C. M. P. F. Batalha, W. Li, K. L. Mpye, N. C. Souza-Pinto, M. S. Naslavsky, E. J. Parra
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Illumina EPIC array
Normalization
Reproducibility
ICC
Online Access:https://doi.org/10.1186/s13148-023-01459-z

Internet

https://doi.org/10.1186/s13148-023-01459-z

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