APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts

APOE4 allele-specific associations between diet, multimodal biomarkers, and cognition among Puerto Rican adults in Massachusetts

BackgroundApolipoprotein E (APOE) is the strongest genetic risk factor for sporadic Alzheimer’s Disease (AD), and the ε4 allele (APOE4) may interact with lifestyle factors that relate to brain structural changes, underlying the increased risk of AD. However, the exact role of APOE4 in mediating inte...

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Bibliographic Details
Main Authors: Yi Guan, Chia Hsin Cheng, Luis I. Bellomo, Sriman Narain, Sherman J. Bigornia, Mahdi O. Garelnabi, Tammy Scott, José M. Ordovás, Katherine L. Tucker, Rafeeque Bhadelia, Bang-Bon Koo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
APOE
blood–brain barrier
neurite orientation dispersion and density imaging
diet
neuroinflammation
blood biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1285333/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1285333/full

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