Structural Requirements in the Hemagglutinin Cleavage Site-Coding RNA Region for the Generation of Highly Pathogenic Avian Influenza Virus

Structural Requirements in the Hemagglutinin Cleavage Site-Coding RNA Region for the Generation of Highly Pathogenic Avian Influenza Virus

Highly pathogenic avian influenza viruses (HPAIVs) with H5 and H7 hemagglutinin (HA) subtypes are derived from their low pathogenic counterparts following the acquisition of multiple basic amino acids in their HA cleavage site. It has been suggested that consecutive adenine residues and a stem-loop...

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Bibliographic Details
Main Authors: Yurie Kida, Kosuke Okuya, Takeshi Saito, Junya Yamagishi, Aiko Ohnuma, Takanari Hattori, Hiroko Miyamoto, Rashid Manzoor, Reiko Yoshida, Naganori Nao, Masahiro Kajihara, Tokiko Watanabe, Ayato Takada
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pathogens
Subjects:
influenza virus
highly pathogenic avian influenza virus
hemagglutinin
cleavage site
RNA secondary structure
nucleotide insertion
Online Access:https://www.mdpi.com/2076-0817/10/12/1597

Internet

https://www.mdpi.com/2076-0817/10/12/1597

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