Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells

Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells

Antiretroviral therapy can successfully suppress HIV-1 replication to undetectable levels but fails to eliminate latent and persistent HIV-1 reservoirs. Recent studies have focused on the immunomodulatory agents such as Toll-like receptor 7 and 8 (TLR7 and TLR8) capable of activating, thereby render...

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Bibliographic Details
Main Authors: Yangyang Li, Zhisong Wang, Ying Hou, Xiaoyu Liu, Junxian Hong, Xuanling Shi, Xiaojie Huang, Tong Zhang, Xuebin Liao, Linqi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
latent reservoir
TLR7 and TLR8 agonists
TNF-α
T cells
NK cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1033448/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1033448/full

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