Metformin Alleviates Pain States by Regulating the Balance of Spinal Synaptic Transmission

Metformin Alleviates Pain States by Regulating the Balance of Spinal Synaptic Transmission

Background: Metformin has been shown to have potent analgesic effects; however, the underlying mechanism of synaptic plasticity mediating analgesia remained ambiguous. Methods: In this study, animal behavioral tests, whole-cell patch‑clamp recording, immunofluorescence staining, and network pharmaco...

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Bibliographic Details
Main Authors: Dongxia Duan, Xiaojin Wu, Usman Ali, Di Wang, Xue Li, Ruimei Liu, Le Ma, Yemeng Mao, Yan Ma
Format: Article
Language:English
Published: IMR Press 2024-01-01
Series:Journal of Integrative Neuroscience
Subjects:
pain
metformin
mepscs
c-fos
glutamatergic transmission
Online Access:https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301006

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https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301006

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