Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors

Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors

The interaction between the tumor suppressor protein p53 and its negative regulator, the MDM2 oncogenic protein, has gained significant attention in cancer drug discovery. In this study, 120 lignans reported from Ferula sinkiangensis and <i>Justicia procumbens</i> were assessed for docki...

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Bibliographic Details
Main Authors: Tagyedeen H. Shoaib, Nihal Abdelmoniem, Rua M. Mukhtar, Amal Th. Alqhtani, Abdullah L. Alalawi, Razan Alawaji, Mashael S. Althubyani, Shaimaa G. A. Mohamed, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Hazem G. A. Hussein, Abdulrahim A. Alzain
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
cancer
MDM2-P53
PPI
Ferula sinkiangensis
<i>Justicia procumbens</i>
lignans
Online Access:https://www.mdpi.com/1420-3049/28/18/6665

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https://www.mdpi.com/1420-3049/28/18/6665

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