Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia

Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia

Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed the safety, side effects, and immunogenicity of a novel, heterologous prime-boost vaccine against Ebol...

Full description

Bibliographic Details
Main Authors: I. V. Dolzhikova, O. V. Zubkova, A. I. Tukhvatulin, A. S. Dzharullaeva, N. M. Tukhvatulina, D. V. Shcheblyakov, M. M. Shmarov, E. A. Tokarskaya, Y. V. Simakova, D. A. Egorova, D. N. Scherbinin, I. L. Tutykhina, A. A. Lysenko, A. V. Kostarnoy, P. G. Gancheva, T. A. Ozharovskaya, B. V. Belugin, L. V. Kolobukhina, V. B. Pantyukhov, S. I. Syromyatnikova, I. V. Shatokhina, T. V. Sizikova, I. G. Rumyantseva, A. F. Andrus, N. V. Boyarskaya, A. N. Voytyuk, V. F. Babira, S. V. Volchikhina, D. A. Kutaev, A. N. Bel'skih, K. V. Zhdanov, S. M. Zakharenko, S. V. Borisevich, D. Y. Logunov, B. S. Naroditsky, A. L. Gintsburg
Format: Article
Language:English
Published: Taylor & Francis Group 2017-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
ad5
ebola
ebola virus disease
heterologous vaccination
prime-boost
vaccine
vsv
zebov
Online Access:http://dx.doi.org/10.1080/21645515.2016.1238535

Internet

http://dx.doi.org/10.1080/21645515.2016.1238535

Similar Items