InSeq analysis of defined Legionella pneumophila libraries identifies a transporter-encoding gene cluster important for intracellular replication in mammalian hosts

InSeq analysis of defined Legionella pneumophila libraries identifies a transporter-encoding gene cluster important for intracellular replication in mammalian hosts

ABSTRACT Legionella pneumophila is an intracellular bacterial pathogen that replicates inside human alveolar macrophages to cause a severe pneumonia known as Legionnaires’ disease. L. pneumophila requires the Dot/Icm Type IV secretion system to deliver hundreds of bacterial proteins to the host cyto...

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Bibliographic Details
Main Authors: Caitlin E. Moss, Craig R. Roy
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
intracellular bacteria
protein secretion
ABC transporters
Legionella pneumophila
transposon mutant sequencing
Online Access:https://journals.asm.org/doi/10.1128/mbio.01955-24

Internet

https://journals.asm.org/doi/10.1128/mbio.01955-24

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