Extracellular Vesicle-Mediated IL-1 Signaling in Response to Doxorubicin Activates PD-L1 Expression in Osteosarcoma Models

Extracellular Vesicle-Mediated IL-1 Signaling in Response to Doxorubicin Activates PD-L1 Expression in Osteosarcoma Models

The expression of programmed cell death ligand 1 (PD-L1) in tumors is associated with tumor cell escape from T-cell cytotoxicity, and is considered a crucial effector in chemoresistance and tumor relapse. Although PD-L1 induction has been observed in patients after chemotherapy treatment, the mechan...

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Bibliographic Details
Main Authors: Su Yati, Atiruj Silathapanasakul, Chakrarin Thakaeng, Mayuree Chanasakulniyom, Napat Songtawee, Sureerut Porntadavity, Peraphan Pothacharoen, Dumnoensun Pruksakorn, Prachya Kongtawelert, Pa-thai Yenchitsomanus, Theerawut Chanmee
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
chemoresistance
extracellular vesicles
immunosuppression
interleukin 1
osteosarcoma
programmed cell death ligand 1
Online Access:https://www.mdpi.com/2073-4409/11/6/1042

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https://www.mdpi.com/2073-4409/11/6/1042

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