Transport of Glial Cell Line-Derived Neurotrophic Factor into Liposomes across the Blood-Brain Barrier: In Vitro and in Vivo Studies

Transport of Glial Cell Line-Derived Neurotrophic Factor into Liposomes across the Blood-Brain Barrier: In Vitro and in Vivo Studies

Glial cell line-derived neurotrophic factor (GDNF) was encapsulated into liposomes in order to protect it from enzyme degradation in vivo and promote its permeability across the blood-brain barrier (BBB). In this study, GDNF conventional liposomes (GDNF-L) and GDNF target sterically stabilized lipos...

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Bibliographic Details
Main Authors: Shaoling Wu, Guoqi Li, Xiao Li, Caina Lin, Ding Yu, Shuo Luan, Chao Ma
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:International Journal of Molecular Sciences
Subjects:
glial cell line-derived neurotrophic factor
target sterically stabilized liposomes
blood-brain barrier
Online Access:http://www.mdpi.com/1422-0067/15/3/3612

Internet

http://www.mdpi.com/1422-0067/15/3/3612

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