Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure

Resistance of Klebsiella pneumoniae to Phage hvKpP3 Due to High-Molecular Weight Lipopolysaccharide Synthesis Failure

ABSTRACT The spread of multidrug resistant and hypervirulent Klebsiella pneumoniae has recently increased. Phages have been considered alternatives for treating infections caused by tenacious pathogens. Our study describes a novel lytic Klebsiella phage, hvKpP3, and we obtained spontaneous mutants,...

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Bibliographic Details
Main Authors: Huaixin Geng, Lingjie Song, Xianggui Yang, Siyu Xing, Rui Wang, Ying Xu, Xu Jia, Guangxin Luan
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
hypervirulent Klebsiella pneumoniae
phage resistance
lipopolysaccharide
glycosyltransferase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04384-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04384-22

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