Salsolinol Attenuates Doxorubicin-Induced Chronic Heart Failure in Rats and Improves Mitochondrial Function in H9c2 Cardiomyocytes

Salsolinol Attenuates Doxorubicin-Induced Chronic Heart Failure in Rats and Improves Mitochondrial Function in H9c2 Cardiomyocytes

Backgrounds: Salsolinol (SAL), a plant-based isoquinoline alkaloid, was initially isolated from Aconiti Lateralis Radix Praeparata (ALRP) and identified as the active cardiotonic component of ALRP. This study was aimed to explore the therapeutic effect and mechanism by which SAL attenuates doxorubic...

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Bibliographic Details
Main Authors: Jianxia Wen, Lu Zhang, Honghong Liu, Jiabo Wang, Jianyu Li, Yuxue Yang, Yingying Wang, Huadan Cai, Ruisheng Li, Yanling Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
Salsolinol
doxorubicin
chronic heart failure
energy metabolism
mitochondrial calcium uniporter
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01135/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01135/full

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