Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways

Human NK Cell Up-regulation of CD69, HLA-DR, Interferon γ Secretion and Cytotoxic Activity by Plasmacytoid Dendritic Cells is Regulated through Overlapping but Different Pathways

Human plasmacytoid dendritic cells secrete high levels of IFNa and are thus implicated in the activation of NK cells. Activated NK cells are characterised by the up-regulation of CD69 and MHC class II DR expression, secretion of IFN g and enhanced cytotoxicity. We show that pDC mediate these process...

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Bibliographic Details
Main Authors: Heather Donaghy, George Rozis, Martin Goodier, Linda Klavinskis, Frances Gotch, Steven Patterson, Adel Benlahrech
Format: Article
Language:English
Published: MDPI AG 2009-01-01
Series:Sensors
Subjects:
dendritic cells
NK cells
cytokines
cytotoxicity
Online Access:http://www.mdpi.com/1424-8220/9/1/386/

Internet

http://www.mdpi.com/1424-8220/9/1/386/

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