Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas

Downregulation of SMOC1 is associated with progression of colorectal traditional serrated adenomas

Abstract Background Aberrant DNA methylation is prevalent in colorectal serrated lesions. We previously reported that the CpG island of SMOC1 is frequently methylated in traditional serrated adenomas (TSAs) and colorectal cancers (CRCs) but is rarely methylated in sessile serrated lesions (SSLs). In...

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Detalhes bibliográficos
Main Authors: Hironori Aoki, Akira Takasawa, Eiichiro Yamamoto, Takeshi Niinuma, Hiro-o Yamano, Taku Harada, Toshiyuki Kubo, Akira Yorozu, Hiroshi Kitajima, Kazuya Ishiguro, Masahiro Kai, Akio Katanuma, Toshiya Shinohara, Hiroshi Nakase, Tamotsu Sugai, Makoto Osanai, Hiromu Suzuki
Formato: Artigo
Idioma:English
Publicado em: BMC 2024-03-01
Colecção:BMC Gastroenterology
Assuntos:
SMOC1
Colorectal cancer
Serrated lesion
Traditional serrated adenoma
Acesso em linha:https://doi.org/10.1186/s12876-024-03175-1

Internet

https://doi.org/10.1186/s12876-024-03175-1

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