The ADP-Ribosylating Toxins of <i>Salmonella</i>

A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen <i>Salmonella</i> is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel A...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Rachel A. Cheng, Martin Wiedmann
التنسيق: مقال
اللغة:English
منشور في: MDPI AG 2019-07-01
سلاسل:Toxins
الموضوعات:
الوصول للمادة أونلاين:https://www.mdpi.com/2072-6651/11/7/416
الوصف
الملخص:A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen <i>Salmonella</i> is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of <i>Salmonella</i> serovars. In this review, we discuss both the classical (SpvB) and novel (typhoid toxin, ArtAB, and SboC/SeoC) ADP-ribosylating toxins of <i>Salmonella</i>, including the structure and function of these toxins and our current understanding of their contributions to virulence.
تدمد:2072-6651