Pennogenin tetraglycoside induces rat myometrial contraction and MLC20 phosphorylation via PLC-IP(3) and RhoA/Rho kinase signaling pathways.

Pennogenin tetraglycoside induces rat myometrial contraction and MLC20 phosphorylation via PLC-IP(3) and RhoA/Rho kinase signaling pathways.

BACKGROUND: Total steroidal saponins extracted from the rhizome of Paris polyphylla Sm. var. yunnanensis (TSSPs) have been widely used in China for the treatment of abnormal uterine bleeding. We previously studied the main active constituents of TSSPs and their structure-activity relationships with...

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Bibliographic Details
Main Authors: Limei Wang, Chao Jia, Zuyin Yu, Xiaolan Liu, Liping Kang, Yue Cong, Yajun Shan, Zhenhu Zhao, Baiping Ma, Yuwen Cong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3520837?pdf=render

Internet

http://europepmc.org/articles/PMC3520837?pdf=render

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