Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways

Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 and TLR4/MYD88/NF-κB pathways, respectively, is involved in alleviating HIR injury. Paeonol is a natural phenolic compound that...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Yasmine F. Ibrahim, Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Seham A. Abdel-Gaber
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
paeonol
hepatic ischemia/reperfusion
Nrf2/HO-1
TLR4/MYD88/NF-κB/TNF-α
Bax/Bcl-2
Online Access:https://www.mdpi.com/2076-3921/11/9/1687

Internet

https://www.mdpi.com/2076-3921/11/9/1687

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