Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients and shows an RLS-like behavioral phenotype. Previou...

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Bibliographic Details
Main Authors: Matilde S. Rodrigues, Samira G. Ferreira, César Quiroz, Christopher J. Earley, Diego García-Borreguero, Rodrigo A. Cunha, Francisco Ciruela, Attila Köfalvi, Sergi Ferré
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
adenosine A<sub>1</sub> receptor
adenosine A<sub>2A</sub> receptor
restless legs syndrome
brain iron deficiency
striatum
cortico-striatal terminals
Online Access:https://www.mdpi.com/1420-3049/27/5/1489

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https://www.mdpi.com/1420-3049/27/5/1489

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