Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes in Cortico-Striatal Terminals: Implications for Restless Legs Syndrome

Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients and shows an RLS-like behavioral phenotype. Previou...

Full description

Bibliographic Details
Main Authors:	Matilde S. Rodrigues, Samira G. Ferreira, César Quiroz, Christopher J. Earley, Diego García-Borreguero, Rodrigo A. Cunha, Francisco Ciruela, Attila Köfalvi, Sergi Ferré
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Molecules
Subjects:	adenosine A<sub>1</sub> receptor adenosine A<sub>2A</sub> receptor restless legs syndrome brain iron deficiency striatum cortico-striatal terminals
Online Access:	https://www.mdpi.com/1420-3049/27/5/1489

Similar Items

Pharmacology of Adenosine Receptors: Recent Advancements
by: Fabrizio Vincenzi, et al.
Published: (2023-09-01)

How Are Adenosine and Adenosine A<sub>2A</sub> Receptors Involved in the Pathophysiology of Amyotrophic Lateral Sclerosis?
by: Akihisa Mori, et al.
Published: (2021-08-01)

Adenosine Receptors Profile in Fibromuscular Dysplasia
by: Claire Guiol, et al.
Published: (2022-11-01)

A<sub>3</sub> Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity
by: Andrea Spinaci, et al.
Published: (2022-01-01)

Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy
by: Rafael Franco, et al.
Published: (2021-10-01)

Expression and Impact of Adenosine A<sub>3</sub> Receptors on Calcium Homeostasis in Human Right Atrium
by: Carmen Tarifa, et al.
Published: (2023-02-01)

Allosteric Interactions between Adenosine A<sub>2A</sub> and Dopamine D<sub>2</sub> Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging
by: Kavya Prasad, et al.
Published: (2021-02-01)

Adenosine A<sub>2A</sub> Receptors Shut Down Adenosine A<sub>1</sub> Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation
by: Cátia R. Lopes, et al.
Published: (2023-04-01)

Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A<sub>2B</sub> Receptor Binding Affinity
by: Marcel Lindemann, et al.
Published: (2021-05-01)

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A<sub>1</sub> Receptor
by: Jeroen Spanoghe, et al.
Published: (2020-12-01)

Antiplatelet Effects of Selected Xanthine-Based Adenosine A<sub>2A</sub> and A<sub>2B</sub> Receptor Antagonists Determined in Rat Blood
by: Monika Kubacka, et al.
Published: (2023-08-01)

A<sub>2A</sub> Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer’s Disease
by: Stefania Gessi, et al.
Published: (2021-09-01)

Adenosine A2A receptors and A2A receptor heteromers as key players in striatal function
by: Sergi eFerre, et al.
Published: (2011-06-01)

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
by: Daniela Catarzi, et al.
Published: (2019-10-01)

Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A<sub>2A</sub> and Dual A<sub>1</sub>/A<sub>2A</sub> Receptor Affinity
by: Michał Załuski, et al.
Published: (2023-09-01)

Development of a Radiofluorinated Adenosine A<sub>2B</sub> Receptor Antagonist as Potential Ligand for PET Imaging
by: Marcel Lindemann, et al.
Published: (2020-04-01)

Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
by: Kelton L. B. dos Santos, et al.
Published: (2020-03-01)

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A<sub>2A</sub> receptor-dependent manner: A<sub>2A</sub> receptor blockade prevents BDNF release and proliferation of microglia
by: Gomes Catarina, et al.
Published: (2013-01-01)

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors, and Efficacy in Animal Models of Depression
by: Flavia Varano, et al.
Published: (2021-07-01)

New Insights into Key Determinants for Adenosine 1 Receptor Antagonists Selectivity Using Supervised Molecular Dynamics Simulations
by: Giovanni Bolcato, et al.
Published: (2020-05-01)

Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist
by: Erine Craey, et al.
Published: (2022-08-01)

Adenosine A<sub>2A</sub> receptor activation reduces recurrence and mortality from <it>Clostridium difficile</it> infection in mice following vancomycin treatment
by: Li Yuesheng, et al.
Published: (2012-12-01)

Hypoxia Depresses Synaptic Transmission in the Primary Motor Cortex of the Infant Rat—Role of Adenosine A<sub>1</sub> Receptors and Nitric Oxide
by: Isabella Zironi, et al.
Published: (2022-11-01)

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?
by: Franck Paganelli, et al.
Published: (2021-02-01)

Characterization and Seasonal Modulation of Adenosine A<sub>1</sub> Receptors in the Arctic Ground Squirrel Brain
by: Zachary Carlson, et al.
Published: (2023-01-01)

Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors
by: Monica Frinchi, et al.
Published: (2020-12-01)

Advantages in Wound Healing Process in Female Mice Require Upregulation A<sub>2A</sub>-Mediated Angiogenesis under the Stimulation of 17β-Estradiol
by: Felipe Troncoso, et al.
Published: (2020-09-01)

Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases
by: Marine Gaudry, et al.
Published: (2020-07-01)

Development of <sup>18</sup>F-Labeled Radiotracers for PET Imaging of the Adenosine A<sub>2A</sub> Receptor: Synthesis, Radiolabeling and Preliminary Biological Evaluation
by: Thu Hang Lai, et al.
Published: (2021-02-01)

Functional Interaction between Adenosine A<sub>2A</sub> and mGlu<sub>5</sub> Receptors Mediates STEP Phosphatase Activation and Promotes STEP/mGlu<sub>5</sub>R Binding in Mouse Hippocampus and Neuroblastoma Cell Line
by: Cinzia Mallozzi, et al.
Published: (2023-09-01)

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A<sub>2B</sub> Adenosine Receptor
by: Ángelo Torres, et al.
Published: (2020-04-01)

Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission
by: Adel E. Khairullin, et al.
Published: (2023-10-01)

Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease
by: Cátia R. Lopes, et al.
Published: (2023-07-01)

Allosteric Antagonism of the A<sub>2A</sub> Adenosine Receptor by a Series of Bitopic Ligands
by: Zhan-Guo Gao, et al.
Published: (2020-05-01)

Adenosine A<sub>3</sub> Receptor (A<sub>3</sub>AR) Agonist for the Treatment of Bleomycin-Induced Lung Fibrosis in Mice
by: Silvia Sgambellone, et al.
Published: (2022-11-01)

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers
by: Carina Herman-de-Sousa, et al.
Published: (2020-03-01)

Molecular Biophysics of Class A G Protein Coupled Receptors–Lipids Interactome at a Glance—Highlights from the A<sub>2A</sub> Adenosine Receptor
by: Efpraxia Tzortzini, et al.
Published: (2023-06-01)

α-Synuclein Aggregates in the Nigro-Striatal Dopaminergic Pathway Impair Fine Movement: Partial Reversal by the Adenosine A<sub>2A</sub> Receptor Antagonist
by: Qionghui Cai, et al.
Published: (2023-01-01)

Adenosine A<sub>2A</sub>Receptors in Substance Use Disorders: A Focus on Cocaine
by: Karolina Wydra, et al.
Published: (2020-06-01)

Synthesis and Biological Evaluation of a Novel <sup>18</sup>F-Labeled Radiotracer for PET Imaging of the Adenosine A<sub>2A</sub> Receptor
by: Thu Hang Lai, et al.
Published: (2021-01-01)