Intranasal immunization of mice with chimera of Salmonella Typhi protein elicits protective intestinal immunity
Abstract Development of safe, highly effective and affordable enteric fever vaccines is a global health priority. Live, oral typhoid vaccines induce strong mucosal immunity and long-term protection, but safety remains a concern. In contrast, efficacy wears off rapidly for injectable, polysaccharide-...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-024-00812-4 |