IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria and Redox Homeostasis

Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system, including neurogenesis, synaptic plasticity and complex cognitive functions. In the present study, we intended to characterize the impact of IGF1R de...

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Bibliographic Details
Main Authors: Susana Cardoso, Icíar P. López, Sergio Piñeiro-Hermida, José G. Pichel, Paula I. Moreira
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomedicines
Subjects:
brain
insulin-like growth factor type 1 receptor
IGF1R-mediated signaling
mitochondria
redox balance
<i>UBC-CreERT2</i>
Online Access:https://www.mdpi.com/2227-9059/9/2/158

Internet

https://www.mdpi.com/2227-9059/9/2/158

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