Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

Although sulfonation plays crucial roles in various biological processes and is frequently utilized in medicinal chemistry to improve water solubility and chemical diversity of drug leads, it is rare and underexplored in ribosomally synthesized and post-translationally modified peptides (RiPPs). Bios...

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Bibliographic Details
Main Authors: Meng Wang, Wen-Wei Li, Zhe Cao, Jianong Sun, Jiang Xiong, Si-Qin Tao, Tinghong Lv, Kun Gao, Shangwen Luo, Shi-Hui Dong
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lanthipeptides
Sulfotransferases
Sulfonation
Biosynthesis
Genome mining
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524000546

Internet

http://www.sciencedirect.com/science/article/pii/S2211383524000546

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