Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation

Abstract Background High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal inflammation, however, the mechanism underlining th...

Full description

Bibliographic Details
Main Authors: Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang, Congfeng Xu, Chunyan Tian, Wei Cai, Jin Wu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cell & Bioscience
Subjects:
Colonic inflammation
High fat diet
Bile acid
Th17 differentiation
Online Access:https://doi.org/10.1186/s13578-023-01109-0

Internet

https://doi.org/10.1186/s13578-023-01109-0

Similar Items