Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation
Abstract Background High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid (DCA) caused by HFD plays significant roles in eliciting intestinal inflammation, however, the mechanism underlining th...
Main Authors: | Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang, Congfeng Xu, Chunyan Tian, Wei Cai, Jin Wu |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-10-01
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Series: | Cell & Bioscience |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13578-023-01109-0 |
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